Eline Slagboom is co-author in Nature Genetics paper
Osteoporosis is a common ailment among the elderly. It is often accompanied by bone fractures which are again bad for life expectancy. Half of people aged 80 and over break a hip die within one year.
It was known that there are hereditary factors in osteoporosis, but which were in the game was unclear so far. Now a publication in Nature Genetics shows that 56 areas on the DNA affect the risk of developing osteoporosis. Fourteen of them also affect the risk of bone fractures. Further research should reveal how the found genetic regions contribute to osteoporosis and whether medicine can intervene in the development of osteoporosis.
This large study was led by the Erasmus MC in which a total of more than 100,000 patients and healthy persons participated. Fifty European, North American, East Asian and Australian cohorts were involved in the research, including the PROSPER / PHASE-cohort of the Leiden University Medical Centre (LUMC).