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Joris Deelen goes to the Gordon Research Conference in Boston and will be giving a talk

02 July 2013 Author: Eka Suchiman

Our PhD student Joris Deelen will talk at the Gordon Research Conference Seminar (Human Genetics & Genomics) in Boston next Saturday. The talk is entitled: Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

Have a look at this link for the full programm of the Gordon Research Conference Seminar.

The Gordon Research Conference Seminar (July 6-7) will be held prior to the Gordon Research Conference (July 7-12, Bryant University Smithfield, RI)

 

Title: Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

Authors: Joris Deelen, Marian Beekman, Hae-Won Uh, Patrik Magnusson, Hélène Blanché, Lene Christiansen, Thomas B.L. Kirkwood, Cornelia M. van Duijn, Claudio Franceschi, Jeanine J. Houwing-Duistermaat, P. Eline Slagboom

Abstract of his talk:

The genetic contribution to the variation in human lifespan, regarded as a polygenic trait, is approximately 25%. We performed a genome-wide association meta-analysis of 7,729 long-lived individuals (≥ 85 years of age) and 16,121 younger controls (< 65 years of age) followed by replication in an additional 13,060 long-lived individuals and 61,156 controls. The analysis showed genome-wide significant association with survival beyond 90 years of age at a novel locus, rs2149954 on chromosome 5q33.3 (OR = 1.10, P = 1.74 x 10-8), and of rs4420638 on chromosome 19q13.32 (OR = 0.72, P = 3.40 x 10-36), representing the previously identified TOMM40/APOE/APOC1 locus. The minor alleles of both SNPs also associate with survival in a prospective meta-analysis (HR = 0.95, P = 0.003 (rs2149954) and HR = 1.07, P = 0.019 (rs4420638)). The intergenic region on chromosome 5q33.3 is the first GWAS-identified locus associated with human longevity besides TOMM40/APOE/APOC1.

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