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Molepi was on Dutch broadcasting with our Leiden Longevity Study Research last Tuesday August 7, 2012

Molepi was on Dutch television with our Leiden Longevity Study research last August 7, 2012.

August 19 2012 Author: Molepi - Molecular Epidemiology

Contribution of Professor Eline Slagboom in Nature Reviews Genetics on Ageing

Together with 5 other authors, Eline Slagboom contributed to an article on genetic studies with regard to ageing, which is published in Nature Reviews Genetics.

July 10 2012 Author: Molecular Epidemiology - Molepi

Manuscript of Elmar Tobi published in PlosOne

The classic ‘Nature’ versus ‘Nurture’ debate is as hot a debate as they come in Science. These past few years a molecular link to the genome has been found to mediate the effect of Nurture on a molecular level; the epigenetic regulation of genes. Indeed we were the first to show in humans that prenatal exposure to the Dutch Famine can leave a persistent mark on DNA methylation, one of these marks, influencing the all important developmental gene IGF2.

We used this early lead to study the influence of the Famine (‘Nurture’) and genetic variation (‘Nature’) in tandem to discover that these two factors can independently influence DNA methylation at the same gene. Moreover, the influences were additive, indicating that ‘Nature’ and ‘Nurture’ can happily come together and sculpt your epigenetic make-up. Maybe the classical debate is more like the battle of the sexes; heated discussions, but even more fraternizing with the enemy.

 

June 04 2012 Author: Eka Suchiman

Interview Steffan Bos in Cicero's May edition

Steffan Bos has been interviewed by LUMC's magazine "Cicero" in it's last May issue.

June 01 2012 Author: Molepi - Molecular Epidemiology

Manuscript of Rudolf Talens in Aging Cell

We are happy to announce that a new manuscript of Rudolf Talens has been accepted by Aging Cell.

May 29 2012 Author: Eka Suchiman

Manuscript of Steffan D Bos is published by Annals of Rheumatic Diseases

Last month a new manuscript of Steffan D Bos PhD, has been published online by Annals of Rheumatic Diseases. 

May 29 2012 Author: Molepi - Molecular Epidemiology

Eline Slagboom will give a talk at the 2nd International Conference on the “Genetics of Aging and Longevity”

Coming Monday April 23rd Eline will give a talk at the 2nd International Conference on the “Genetics of Aging and Longevity” in Moscow, Russia.

Her talk is entitled: "Genetic, epigenetic and genomic determinants of human longevity. "

April 20 2012 Author: Molepi - Molecular Epidemiology

Eline Slagboom is co-author in Nature Genetics paper

Osteoporosis is a common ailment among the elderly. It is often accompanied by bone fractures which are again bad for life expectancy. Half of people aged 80 and over break a hip die within one year.

It was known that there are hereditary factors in osteoporosis, but which were in the game was unclear so far. Now a publication in Nature Genetics shows that 56 areas on the DNA affect the risk of developing osteoporosis. Fourteen of them also affect the risk of bone fractures. Further research should reveal how the found genetic regions contribute to osteoporosis and whether medicine can intervene in the development of osteoporosis.

April 20 2012 Author: Molepi - Molecular Epidemiology

Anika Vaarhorst's Paper has been accepted by Circulation Cardiovascular Genetics

Anika's paper has been accepted by Circulation Cardiovascular Genetics. Please follow this link to read the prepublication version of the paper or a short summary below...

March 12 2012 Author: Eka Suchiman

Molepi hosts the 1st Annual Meeting of the IDEAL Consortium

The IDEAL consortium will have their first annual meeting from March 1-3, 2012.

February 29 2012 Author: Molecular Epidemiology - Molepi

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