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Evelyn Houtman

PhD Student | Tel.: +31 (0) 71 526 9786send mail

evelyn.jpgEvelyn Houtman (born 1991) started her PhD in May 2016 at the department of Molecular Epidemiology (LUMC). After receiving her high school diploma she studied Biomedical Sciences at the University of Leiden from 2009-2015. During her education she performed various researches at different departments:

  • The identification of genetic variants in families with short stature by using a filtering tree for clinical applications and the optimisation of a SNP test to control for sample swap. (4 month, clinical genetics)
  • The effects of inhibition of inflammation (via addition of salsalate or TLR-4) in the brain on the function of brown adipose tissue in ApoE3*Leiden.CETP mice on a high-fat diet. (6 months, endocrinology)
  • The identification of the underlying mechanism of osteoarthritis (OA) in the GARP study using exome sequencing data. The goals was not to find the causal mutations for all siblings, but to identify pathways that play a more general role in OA. (11 months, Molecular Epidemiology)

Her PhD research at the department of molecular epidemiology will be supported by a Reumafonds grant and will focus on attenuation of intra-articular thyroid signalling in a osteoarthritis (OA) explant model. In this OA explant model, cartilage damage is induced via overloading and one of the goals is to investigate whether this damage can be lessened, stopped and maybe even reversed.

 

Publications:

2016 Bomer N, den Hollander W, Suchiman H, Houtman E, Slieker RC, Heijmans BT, Slagboom PE, Nelissen RG, Ramos YF, Meulenbelt I. Neo-cartilage engineered from primary chondrocytes is epigenetically similar to autologous cartilage, in contrast to using mesenchymal stem cells. Osteoarthritis Cartilage doi: 10.1016/j.joca.2016.03.009

 

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