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Marian Beekman

Senior Scientist | Tel.: +31 (0) 71 526 9735send mail

 Marian Beekman (1972) was trained as a biomedical scientist and studies the role of genetic and phenotypic variation in human healthy ageing and longevity. Her research is focused on identifying variation in genomic regions that contribute to metabolic healthy and longevity, where variation in gene expression, DNA sequence and methylation marks are of interest. Integration of genetic data with a wide scale of omics data to investigate how genetic variation can contribute to healthy ageing is one of the major goals in her studies. Therefore, she combines the in depth phenotyping of the participants of the Leiden Longevity Study (Leiden LangLeven Studie) with the data analysis in the setting of molecular epidemiology.

Area of interest:

  • Genetics
  • Family studies
  • Integration of omics data


Main study population:

Leiden Longevity Study (Leiden LangLeven Studie):

  • 644 nonagenarian siblings from 421 families
  • 1671 offspring and 744 partners thereof as population controls
    • DNA
    • RNA (PAXgene)
    • Unine (first morning void)
    • Plasma (EDTA, citrate)
    • Serum (fasted, non-fasted)
  • Illumina OmniExpress, 660W-quad SNP array
  • In 220 nonagenarian: Complete Genomics whole genome sequence
  • Biocrates metabolomics platform
  • LC-MS Lipidomics platform Netherlands Metabolomics Center, Leiden
  • IgG glycosilation platform Parasitology, LUMC, Leiden
  • 1H-NMR metabolomics platform Parasitology, LUMC, Leiden


PhD Students supervised:

Erik van den Akker, thesis title: 'Computational biology in human aging - an omics data integration approach' in 2015
Joris Deelen, thesis title: 'Genetic and biomarker studies of human longevity' in 2014 (cum laude)
Willemijn Passoors, thesis title: 'Transcriptomic studies in human ageing and longevity' in 2013 

Selected publications:

Google Scholar
2010 Beekman PNAS.pdf 
2011 Deelen Aging Cell.pdf 
2011 Slagboom review.pdf


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