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posted on 2017/03/03

Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice

Zwamborn,R.A., Slieker,R.C., Mulder,P.C., Zoetemelk,I., Verschuren,L., Suchiman,H.E., Toet,K.H., Droog,S., Slagboom,P.E., Kooistra,T., Kleemann,R., Heijmans,B.T.

Sci.Rep. 2017/03/03, Volume 7, Number , 43261

posted on 2017/02

A framework for the detection of de novo mutations in family-based sequencing data

Francioli,L.C., Cretu-Stancu,M., Garimella,K.V., Fromer,M., Kloosterman,W.P., Samocha,K.E., Neale,B.M., Daly,M.J., Banks,E., DePristo,M.A., de Bakker,P.I.

Eur.J.Hum.Genet. 2017/02, Volume 25, Number 2, 227-233

posted on 2017/02

Human Plasma N-glycosylation as Analyzed by Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Ion Cyclotron Resonance-MS Associates with Markers of Inflammation and Metabolic Health

Reiding,K.R., Ruhaak,L.R., Uh,H.W., El,Bouhaddani S., van den Akker,E.B., Plomp,R., McDonnell,L.A., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M., Wuhrer,M.

Mol.Cell Proteomics. 2017/02, Volume 16, Number 2, 228-242

posted on 2017/01/27

Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution

van Iterson,M., van Zwet,E.W., Heijmans,B.T.

Genome Biol. 2017/01/27, Volume 18, Number 1, 19

posted on 2017/01/26

Molecular dissection of germline chromothripsis in a developmental context using patient-derived iPS cells

Middelkamp,S., van Heesch,S., Braat,A.K., de Ligt,J., van Iterson,M., Simonis,M., van Roosmalen,M.J., Kelder,M.J., Kruisselbrink,E., Hochstenbach,R., Verbeek,N.E., Ippel,E.F., Adolfs,Y., Pasterkamp,R.J., Kloosterman,W.P., Kuijk,E.W., Cuppen,E.

Genome Med. 2017/01/26, Volume 9, Number 1, 9-

posted on 2017/01/10

The complex genetics of gait speed: genome-wide meta-analysis approach

Ben-Avraham,D., Karasik,D., Verghese,J., Lunetta,K.L., Smith,J.A., Eicher,J.D., Vered,R., Deelen,J., Arnold,A.M., Buchman,A.S., Tanaka,T., Faul,J.D., Nethander,M., Fornage,M., Adams,H.H., Matteini,A.M., Callisaya,M.L., Smith,A.V., Yu,L., De Jager,P.L., Evans,D.A., Gudnason,V., Hofman,A., Pattie,A., Corley,J., Launer,L.J., Knopman,D.S., Parimi,N., Turner,S.T., Bandinelli,S., Beekman,M., Gutman,D., Sharvit,L., Mooijaart,S.P., Liewald,D.C., Houwing-Duistermaat,J.J., Ohlsson,C., Moed,M., Verlinden,V.J., Mellstrom,D., van der Geest,J.N., Karlsson,M., Hernandez,D., McWhirter,R., Liu,Y., Thomson,R., Tranah,G.J., Uitterlinden,A.G., Weir,D.R., Zhao,W., Starr,J.M., Johnson,A.D., Ikram,M.A., Bennett,D.A., Cummings,S.R., Deary,I.J., Harris,T.B., Kardia,S.L., Mosley,T.H., Srikanth,V.K., Windham,B.G., Newman,A.B., Walston,J.D., Davies,G., Evans,D.S., Slagboom,E.P., Ferrucci,L., Kiel,D.P., Murabito,J.M., Atzmon,G.

Aging (Albany.NY) 2017/01/10, Volume 9, Number 1, 209-246

posted on 2017/01/05

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

Wahl,S., Drong,A., Lehne,B., Loh,M., Scott,W.R., Kunze,S., Tsai,P.C., Ried,J.S., Zhang,W., Yang,Y., Tan,S., Fiorito,G., Franke,L., Guarrera,S., Kasela,S., Kriebel,J., Richmond,R.C., Adamo,M., Afzal,U., Ala-Korpela,M., Albetti,B., Ammerpohl,O., Apperley,J.F., Beekman,M., Bertazzi,P.A., Black,S.L., Blancher,C., Bonder,M.J., Brosch,M., Carstensen-Kirberg,M., de Craen,A.J., de Lusignan,S., Dehghan,A., Elkalaawy,M., Fischer,K., Franco,O.H., Gaunt,T.R., Hampe,J., Hashemi,M., Isaacs,A., Jenkinson,A., Jha,S., Kato,N., Krogh,V., Laffan,M., Meisinger,C., Meitinger,T., Mok,Z.Y., Motta,V., Ng,H.K., Nikolakopoulou,Z., Nteliopoulos,G., Panico,S., Pervjakova,N., Prokisch,H., Rathmann,W., Roden,M., Rota,F., Rozario,M.A., Sandling,J.K., Schafmayer,C., Schramm,K., Siebert,R., Slagboom,P.E., Soininen,P., Stolk,L., Strauch,K., Tai,E.S., Tarantini,L., Thorand,B., Tigchelaar,E.F., Tumino,R., Uitterlinden,A.G., van Duijn,C., van Meurs,J.B., Vineis,P., Wickremasinghe,A.R., Wijmenga,C., Yang,T.P., Yuan,W., Zhernakova,A., Batterham,R.L., Smith,G.D., Deloukas,P., Heijmans,B.T., Herder,C., Hofman,A., Lindgren,C.M., Milani,L., van der Harst,P., Peters,A., Illig,T., Relton,C.L., Waldenberger,M., Jarvelin,M.R., Bollati,V., Soong,R., Spector,T.D., Scott,J., McCarthy,M.I., Elliott,P., Bell,J.T., Matullo,G., Gieger,C., Kooner,J.S., Grallert,H., Chambers,J.C.

Nature 2017/01/05, Volume 541, Number 7635, 81-86

posted on 2017/01/05

Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis

van Rooij,F.J., Qayyum,R., Smith,A.V., Zhou,Y., Trompet,S., Tanaka,T., Keller,M.F., Chang,L.C., Schmidt,H., Yang,M.L., Chen,M.H., Hayes,J., Johnson,A.D., Yanek,L.R., Mueller,C., Lange,L., Floyd,J.S., Ghanbari,M., Zonderman,A.B., Jukema,J.W., Hofman,A., van Duijn,C.M., Desch,K.C., Saba,Y., Ozel,A.B., Snively,B.M., Wu,J.Y., Schmidt,R., Fornage,M., Klein,R.J., Fox,C.S., Matsuda,K., Kamatani,N., Wild,P.S., Stott,D.J., Ford,I., Slagboom,P.E., Yang,J., Chu,A.Y., Lambert,A.J., Uitterlinden,A.G., Franco,O.H., Hofer,E., Ginsburg,D., Hu,B., Keating,B., Schick,U.M., Brody,J.A., Li,J.Z., Chen,Z., Zeller,T., Guralnik,J.M., Chasman,D.I., Peters,L.L., Kubo,M., Becker,D.M., Li,J., Eiriksdottir,G., Rotter,J.I., Levy,D., Grossmann,V., Patel,K.V., Chen,C.H., Ridker,P.M., Tang,H., Launer,L.J., Rice,K.M., Li-Gao,R., Ferrucci,L., Evans,M.K., Choudhuri,A., Trompouki,E., Abraham,B.J., Yang,S., Takahashi,A., Kamatani,Y., Kooperberg,C., Harris,T.B., Jee,S.H., Coresh,J., Tsai,F.J., Longo,D.L., Chen,Y.T., Felix,J.F., Yang,Q., Psaty,B.M., Boerwinkle,E., Becker,L.C., Mook-Kanamori,D.O., Wilson,J.G., Gudnason,V., O'Donnell,C.J., Dehghan,A., Cupples,L.A., Nalls,M.A., Morris,A.P., Okada,Y., Reiner,A.P., Zon,L.I., Ganesh,S.K.

Am.J.Hum.Genet. 2017/01/05, Volume 100, Number 1, 51-63

posted on 2017/01

The role of epigenetics in osteoarthritis: current perspective

Ramos,Y.F., Meulenbelt,I.

Curr.Opin.Rheumatol. 2017/01, Volume 29, Number 1, 119-129

posted on 2017/01

Identification of context-dependent expression quantitative trait loci in whole blood

Zhernakova,D.V., Deelen,P., Vermaat,M., van Iterson,M., van Galen,M., Arindrarto,W., van 't,Hof P., Mei,H., van Dijk,F., Westra,H.J., Bonder,M.J., van Rooij,J., Verkerk,M., Jhamai,P.M., Moed,M., Kielbasa,S.M., Bot,J., Nooren,I., Pool,R., van Dongen,J., Hottenga,J.J., Stehouwer,C.D., van der Kallen,C.J., Schalkwijk,C.G., Zhernakova,A., Li,Y., Tigchelaar,E.F., de Klein,N., Beekman,M., Deelen,J., van Heemst,D., van den Berg,L.H., Hofman,A., Uitterlinden,A.G., van Greevenbroek,M.M., Veldink,J.H., Boomsma,D.I., van Duijn,C.M., Wijmenga,C., Slagboom,P.E., Swertz,M.A., Isaacs,A., van Meurs,J.B., Jansen,R., Heijmans,B.T., 't Hoen,P.A., Franke,L.

Nat.Genet. 2017/01, Volume 49, Number 1, 139-145

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